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Welcome to the Maruvka Lab website

The Cancer Evolution Lab

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Research

We are developing new tools to analyze cancer evolution and are applying our findings in a clinical setting.

Recent technological developments in generating biological data, such as next-generation DNA/RNA sequencing, has led to an exponential growth of biological data. This is particularly true of cancer data, as DNA sequencing is a routine procedure at many medical centers. The main bottleneck for research is therefore not in data generation but rather in interpreting this wealth of data. In our lab, we develop new algorithms and computational tools for analyzing cancer data, and apply them to the abundance of newly available data, with the goal of generating new biological insights and medical diagnostic tools.
While our interest spans all aspects of cancer bioinformatics, our current main focus is on the genomics of tumors that develop due to a deficiency in one of the DNA repair pathways.

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As examples, two of the lab's current projects include:

  • 1. Cancer early detection using cell-free DNA: We are developing computational methods to analyze cell-free DNA in the blood in order to be able to detect traces of cancerous DNA from the blood. This may be useful both for early detection of cancer and for monitoring the relapse of previous tumors.
  • 2. Preventative vaccine for colon cancer for Lynch Syndrome patients: A familial syndrome with a predisposition to colon cancer called Lynch Syndrome is characterized by highly frequent mutations. We are analyzing samples from an early cancerous lesion, and predicting which of these mutations are likely to lead to an immune response, and therefore can be used for a preventive vaccine against tumor development.

Our Team

The lab is multidisciplinary and candidates backgrounds can range from medical
studies or basic biology to computer science and applied mathematics or the like.

Yosef Maruvka

Principal Investigator

Yosef Maruvka - Principal Investigator

To read about my research see Research section

Shai Naparstek

Research associate/Lab manager

Shai Naparstek - Research associate/Lab manager

Hi!, I'm the new lab manager

Hagay Ladany

PhD student

Hagay Ladany - PhD student

My research is based on the assumption that random mutations arising during DNA replication in normal, non-cancerous stem cells may contribute to cancer development. Therefore, estimating the mutation-rate in which an individual accumulates mutations can help to predict cancer development for each individual, as well as predict characteristics of the emergence of drug resistance for each individual and each drug.

Jorge Cano Nistal

PhD student

Jorge Cano Nistal -PhD student


Born in León, Spain. B.Sc. in Biology, M.Sc. in Innovation in Biomedicine & Health Science (University of León) and passionate about Mathematics, Physics and Scientific Communication as well. My passion for science started at an early age and grew over the years.Now, as a PhD Student at Maruvka Lab, I am willing to help people by researching in the amazing field of Cancer Bioinformatics. As one of the greatest scientists of all times said once: “If I have seen further, it is by standing upon the shoulder of giants”.

Daniel Gorvich

MSc student

Daniel Gurevich - M.sc. student


- B.Sc. in Biotechnology and Food Engineering from the Technion- Israel Institute of Technology (2020).
- Joined the team on March 2020.

Research topic


Characterization of cancer by using ensemble learning algorithms.

Gaia Frant

MSc student

Gaia Frant (MSc student)

I have received my B.Sc in Biotechnology and Food Engineering from the Technion.
My research is currently focused on better characterizing the MMR system through the analysis of different cancer types.

Guy Shani

MSc student

Guy Shani - MSc student

I have just received my B.Sc in material engineering and physics.
I am developing computational tools that can detect cancerous DNA in the cell free DNA. These tools can be used for early detection.

Avraham Kahan

Research assistant

Avraham Kahan (Research assistant)

I am interested in the development of efficient algorithms and heuristics to model and analyze biological systems.
Currently, my research is focused on developing computational tools to deduce molecular characteristics of tumors from imaging and sequencing data

Sahar (Haozhen Hong)

MSc student

Haozhen Hong

Hi!
I am Haozhen Hong from China.
I got the B.Sc degree from GTIIT – Guangdong Technion in China and then joined the lab in October 2021.
Currently, my general research direction is to analyse AML cancer by nanopore sequencing.

Stav Naky

MSc student

Stav Naky

Hi!
I have a B.Sc in Biotechnology from Tel-Hai college, summa cum laude.
I've also taken several courses related to Computer Science, and have been a bioinformatician at the Faculty of Medicine, Technion for the past year at the Preger Lab.
Currently, I'm an M.Sc student, and my project is going to be about diagnosing cancer from cell-free DNA (cfDNA) of patients, within low-coverage whole genome sequencing.

Ofek (Yu LIN)

MSc student

Ofek (MSc student)

Hi!
I am Yu LIN, also known as Ofek, from China.
I graduated with a BSc degree in Biotechnology and Food Engineering from Guangdong Technion in 2021.
I joined Maruvka Lab as a Master's student in summer 2021.
I will take part in the laboratory and computational side of oncology research.

Dana Dayan

Research assistant

Dana Dayan

Hi!
I am currently working as a Research Assistant.

Betzalel Evans

Summer intern

Betzalel Evans (International intern)

Summer 2021
I am a 2nd year Chemical Engineering Student at the Cooper Union in New York City.
I will be working in the lab under the title of "International summer intern".

Dr. Amir B. Cohanim

Research associate

Dr. Amir B. Cohanim

2021-2022
I am a computational biologist. Chromatin structure and Epigenetics were my main fields of research during my doctoral- and postdoctoral- studies, at the Technion, and ENS - Paris. Currently I am working in Dr. Yosef Maruvka Lab on Microsatellite Instability (MSI).

Gavriel Hannuna

Research assistant

Gavriel Hannuna

2021-2022
The aim of my research is to analyze the mutational pattern of 126 mammalian species, study the mutational events that shaped the evolution of those species, and compare the results with the data we have on humans.

Chen Sharon

B.Sc Project

Chen Sharon

2021-2022
I am a fourth-year B.Sc. student at the Faculty of Biotechnology and Food Engineering.
Currently, I am working on my B.Sc research project, on the topic of somatic mutations in pediatric acute myeloid leukemia.

Open positions

We are looking for an experimentalist post-doc with a background in cell-biology and genomics. Previous experience in cancer research is an advantage. We are also looking for a computational PhD student for a tool development project. Relevant background, computer science, mathematics, physics or similar. While we have enough personnel with biological background, we may have some opening for excellent PhD student.
Please contact us at: [email protected]
Thanks,
Yosi

Collaborators

Foresee Genomics

Foresee Genomics logo

Our lab collaborates with a startup company Foresee Genomics in developing inexpensive and easy-to-use sequencing protocols based on Nanopore sequencing technology. Foresee Genomics develops a combined system of molecular biology and bioinformatics. An enabling technology with the purpose to increase the accuracy of the currently error-prone nanopore-based 4th generation DNA sequencing technology, transforming it into a technology that would be suitable for sensitive diagnostics. The nanopore sequencing platform is significantly inexpensive in comparison to all other NGS platforms. The combined system of Foresee Genomic and the nanopore sequencer is an end-to-end solution for genomic diagnostics which is accurate and affordable. We give labs the capability to do comprehensive molecular testing at an unprecedented price.


Grants

In Memoriam Icon of memorial candle

Due to the loss of two dear and beloved people, my research shifted from a theoretical focus to a more applied cancer focus.

image of abraham Colton

My father-in-law, Abraham Colton,
passed away at age 77 from Lymphoma cancer

image of dov Eisenbach

My cousin, Dov (Irad) Eisenbach,
passed away at age 33 from tongue cancer.

Contact

Maruvka lab

Applications and CVs can be sent to our email.
For any questions or concerns please contact us by email or phone.

Technion – Israel Institute of Technology Haifa, 3200, Emerson Building 3-4

[email protected]

Yosi: +972-77-8871275

Lab: +972-77-8871902


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11-Oct-2022